a.inhibition of PFK2
b.Activation of Fructose 2,6bisphosphatase
c.increase in glucagon
d.increase in Fructose2,6bis phosphate
When there is an abundant supply of glucose, the
concentration of fructose 2,6-bisphosphate increases, stimulating glycolysis by
activating phosphofructokinase-1 and inhibiting fructose 1,6-bisphosphatase. In
the fasting state, glucagon stimulates the production of cAMP, activating
cAMP-dependent protein kinase, which in turn inactivates phosphofructokinase-2
and activates fructose 2,6-bisphosphatase by phosphorylation. Hence,
gluconeogenesis is stimulated by a decrease in the concentration of fructose
2,6-bisphosphate, which inactivates phosphofructokinase-1 and relieves the
inhibition of fructose 1,6-bisphosphatase.[Harper 28th edition]
Answer is increase in
Fructose2,6bis phosphate
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