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Tuesday, 10 January 2012

4. All except occurs on Decrease in liver glucose level :


            a.inhibition of PFK2
            b.Activation of Fructose 2,6bisphosphatase
             c.increase in glucagon
             d.increase in Fructose2,6bis phosphate
When there is an abundant supply of glucose, the concentration of fructose 2,6-bisphosphate increases, stimulating glycolysis by activating phosphofructokinase-1 and inhibiting fructose 1,6-bisphosphatase. In the fasting state, glucagon stimulates the production of cAMP, activating cAMP-dependent protein kinase, which in turn inactivates phosphofructokinase-2 and activates fructose 2,6-bisphosphatase by phosphorylation. Hence, gluconeogenesis is stimulated by a decrease in the concentration of fructose 2,6-bisphosphate, which inactivates phosphofructokinase-1 and relieves the inhibition of fructose 1,6-bisphosphatase.[Harper 28th edition]
 Answer is increase in Fructose2,6bis phosphate

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