Pages

Tuesday, 10 January 2012

7.Common enzyme in cholestrol and ketone metabolism



    a. HMG coA reductase
    b HMG coA lyase
   c HMG coA synthase
  d. Thiolase
answer -HMG CoA Synthase
 
Cholesterol Synthesis





 

 Ketogenesis


Acetoacetyl-CoA, which is the starting material for ketogenesis, also arises directly from the terminal fourcarbons of a fatty acid -oxidation(Figure 22–7). Condensation of acetoacetyl-CoA with another molecule of
acetyl-CoA by 3-hydroxy-3-methylglutaryl-CoA synthase forms 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA)[Harper28th Chapter 22]Diagram 22-7

Expl-Acetoacetyl Co A is the starting material for ketogenesis..Acetyl CoA released by Oxidation is added to the AcetoAcetyl Co A To Form HMG CoA.So Thiolasecannot be considered a part of Ketogenesis according to Harper.
But many books says Acetyl CoA is the staarting material.But Harper doesnt.


2 comments:

  1. i find these really useful mam..thank u very much mam..

    ReplyDelete
  2. This comment has been removed by the author.

    ReplyDelete